Trevor Moore, a comedian and co-founder of the popular sketch comedy show “The Whitest Kids U’Know,” which appeared on the Independent Film Channel, died on Saturday in Los Angeles. He was 41.

His death was confirmed by the Los Angeles County medical examiner-coroner, who said that Mr. Moore had died in a yard on a residential block in the Franklin Hills section of the city, the same block where public records showed that he had lived.

He was killed in an accident, according to a statement from his wife, Aimee Carlson, that was released by his manager, Kara Welker. The statement did not provide details of the accident, and Ms. Welker said she did not have additional information. The medical examiner’s office said it would conduct an autopsy.

Mr. Moore released a solo comedy album, “Drunk Texts to Myself”; hosted a one-hour special on Comedy Central; and co-directed, co-wrote and starred in the films “Miss March” (2009) and “The Civil War on Drugs” (2011).

But he is best known for his work on “Whitest Kids U’Know,” which ran for five seasons starting in 2007. Zany and wry, it sought to wring laughs out of thorny issues like police brutality, the war on drugs and student debt.

One writer at the website Salon last year said the show “eerily foresaw the Trump era.” Other times, the show veered into the absurd. After going off the air, it developed a following online, and its YouTube channel has more than 100 million total views.

Mr. Moore often rooted his comedy in terrain his audiences could recognize — a park with an old friend, a modern-day White House news conference — and injected each scenario with dizzying amounts of lunacy and humor.

In one memorable sketch, a White House press secretary reveals more and more details about an unlikely turn of events on a secret United States space station on the moon that has been taken over by bears.

“We believe they may be involved in some sort of intergallatic drug cartel, perhaps affiliated with one of the interstellar wizard alliances,” the press secretary deadpans. Stunned reporters try to absorb the shocking news when one finally asks, “You wouldn’t happen to be invading Iran today, would we?” The press secretary pauses, then smiles wryly and says, “You got me.”

In 2019, Mr. Moore brought his idiosyncratic sensibilities to the talk show format, and began hosting “The Trevor Moore Show” on Comedy Central. Its early episodes had titles like “Achieving World Peace with Flat Earth Theory” and “Why is Everyone So Horny All the Time?”

“See, the worst part about dying,” Mr. Moore said on the show in June, “is that you don’t get to hear all the nice things said about you after you’re gone.”

Born on April 4, 1980, in Montclair, N.J., Mr. Moore was raised in Charlottesville, Va., by his parents, Mickey and Becki Moore, popular Christian rock singers, according to Vanity Fair and the website IMDb.

At 16, Mr. Moore began creating weekly cartoons for local newspapers in Virginia, and by 19 he had written and produced a weekly sketch comedy program, “The Trevor Moore Show,” for local television stations, according to IMDb.

Mr. Moore graduated with a degree in film from the School of Visual Arts in New York City. In 2010, he married Ms. Carlson. In addition to his wife and parents, Mr. Moore is survived by a 3-year-old son, August. He is also survived by a sister, Lila Haile.

News of Mr. Moore’s death drew an outpouring of praise for the comedian from collaborators and admirers.

On Instagram, the comedian James Adomian of IFC’s “Comedy Bang! Bang!” said Mr. Moore “was a magnetic friend to all, who thought everything was unstoppably hilarious no matter how scary or hopeless — this sardonic gallows humor was a beacon and a guide to me and many others in dark times.”

Referring to two sketch comedy shows with strong cult followings, David Gallaher, who has written for Marvel and DC Comics, said on Twitter that Mr. Moore “blended the BEST of The State and Kids In The Hall to create something beautiful, subversive, and contemporary.”

Neil Vigdor contributed reporting and Kitty Bennett contributed research.